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This is D Craig Hooper, PhD, and Bernhard Dietzschold, DVM, of Thomas Jefferson University Thomas Jefferson University received a National Institutes of Health NIH $48 million grant to test a new rabies vaccine with the potential to cure the virus infection, even after it has made its way into a person’s central nervous system CNS Today, if an unvaccinated person is infected with rabies and it spreads to the brain, there is little chance for survival
The grant to study the new vaccine, which was developed by Jefferson researchers, including the principal investigator for the project, D Craig Hooper, PhD, Director of the Center for Neurovirology will be shared among Jefferson, the University of Georgia, the Medical College of Wisconsin and the Institute for Hepatitis and Virus Research Pennsylvania Commonwealth Institute
Treating rabies
The rabies vaccine used today to protect people from the virus is the same one used to treat a person who has been bitten by a rabid dog, raccoon, bat or other animal If the vaccine series and preformed rabies virus neutralizing antibodies are administered shortly after the bite, the virus is destroyed and the person almost always survives
For someone who unknowingly contracts rabies or is not treated, flu-like symptoms generally begin to manifest within a few weeks, meaning the virus has reached the nervous system and survival is unlikely About 50,000 people die worldwide every year after being infected with the virus, most of whom live in developing nations where dog rabies is not controlled and vaccines for humans can be hard to get and expensive
A new version of the rabies vaccine that is effective after someone develops the first signs of the disease could be the saving grace for some of these people
Making a vaccine
Recently, several patients whose brains were infected with the virus survived, confirming studies in animal models that under certain circumstances the immune system can clear rabies virus from the brain
Dr Hooper, along with Jefferson colleagues, Bernhard Dietzschold, DVM, a professor of Microbiology and Immunology and Milosz Faber, PhD a research instructor in microbiology and immunology, hypothesized that a weaker strain of the virus can be used to cause the immune system to eliminate more deadly virus strains
Studying the mechanisms by which the immune system can wipe the virus from the CNS and the development of weakened virus strains with improved safety profiles that can induce this process have been the focus of their research, and is the basis for the vaccine being tested in the NIH-funded study
“This is the first translational work to be done on live-attenuated rabies vaccines with the potential to clear wild-type rabies virus from the central nervous system,” said Dr Hooper, who is also an associate professor of Cancer Biology with a joint appointment in Neurological Surgery at Jefferson “This live attenuated vaccine can clear a pre-existing infection with a highly lethal virus from the brains of mice, an outcome that we have never seen before
“This grant lets us further study the potential that this vaccine has for humans, will give us information on biomarkers of rabies virus infection and the protective immune response, and will help us predict the maximum post-infection delay where treatment may be possible”
Also, if it is found safe and effective, the vaccine will serve as a foundation to develop similar reagents for the treatment of epidemic virus infections of the brain, a major health concern, particularly with respect to bioterrorism
“The ultimate goal is to develop a single vaccine that can safely clear several types of encephalitis viruses from the CNS tissues,” he said
UIC Cancer Center Seminar
Rachel Caskey, MD, MaPP Assistant Professor, Internal Medicine and Pediatrics, College of Medicine Member, Cancer Control and Population Science Program
Thursday, September 1, 2011 Noon to 1 p.m. 5157 College of Medicine Research Building 909 S. Wolcott St.
Hosted by the Population Health, Behavior and Outcomes Program.
All interested physicians, researchers, post-docs, students and technicians invited.
For further information, please contact the UIC Cancer Center extension 3-4326.
The ‘Clean’ recipes call for a lot of juices, smoothies and soups, as you consume two liquid meals a day and dairy and wheat are no-nos.
The recipes are designed by Jill Pettijohn, a nurse and raw foods chef who runs a successful juice-cleanse delivery service in New York. But with a good juicer and blender you can do it yourself, and there’s plenty of online support.
Typical detox day
Breakfast: Green smoothie. Hot water and lemon or herbal tea.
Mid-morning: Snack or herbal tea.
Lunch: Steamed bass with fennel, parsley and capers.
Mid-afternoon: Snack or herbal tea.
Dinner: Chilled cucumber soup with mint.
Drink plenty of pure water every day.
Apple cider vinegar has long been used as a general health tonic. More recently its properties as an all natural weight loss product have brought about a renewed surge in its popularity. Apple cider vinegar is simply a composition that is made by fermenting apple juice. First apple juice is fermented to an apple cider and then further fermented to make apple cider vinegar. This amazing product is full of healthful enzymes and acids. Because of the fermenting process, apple cider vinegar maintains the nutrients found in apples in their raw state. As such, this vinegar is chalked full of minerals, vitamins, elemental sugars and pectin. Pectin is important for the intestines as it helps to attract water into them thereby lubricating and hydrating out insides. Moreover, for those with IBS or other intestinal and stomach ailments, apple cider vinegar can help with detoxification and constipation.Because of its help with the above intestinal complaints, apple cider vinegar also makes a great detoxification aid. It is antiseptic and helps to fight bacterial growth both inside and outside of the body. It can be used to help with the break down of fats and proteins thereby improving the bioavailability of nutrients in the body. This is important especially for those who suffer from sluggish digestion or malabsorption problems—again common among IBS patients.Apple cider vinegar can also help to restore the body’s natural Ph balance. This means that you can reduce the acidity in your body by taking this natural remedy. For those that suffer from gallbladder attacks, it is also said that a teaspoon or two of apple cider vinegar in a glass of apple juice can help stop or at least lessen an attack and even help to possibly dissolve gallstones altogether.Finally, apple cider vinegar can be a helpful addition to any weight loss program. Apple cider vinegar is known to increase weight loss by breaking down fat and helping the body to let go of unwanted stores. Apple cider vinegar is a great all round health tonic. Used internally or externally, apple cider vinegar is safe and effective. Add a few teaspoons or more to your salad dressing or simply slip some into a glass of apple juice for an added zing. Organic apple cider vinegar is now available and is a better buy than traditional varieties.
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